ZIVVI PDRN SERUM
PDRN Repair Serum packaging and bottle on a beige background with text highlighting its features.
Close-up of a woman's face with skincare steps indicated, including washing with a gentle cleanser and applying serum.
ZIVVI PDRN SERUM
ZIVVI PDRN SERUM
ZIVVI PDRN SERUM
ZIVVI PDRN SERUM
ZIVVI PDRN SERUM
PDRN Repair Serum packaging and bottle on a beige background with text highlighting its features.
Close-up of a woman's face with skincare steps indicated, including washing with a gentle cleanser and applying serum.
ZIVVI PDRN SERUM
ZIVVI PDRN SERUM
ZIVVI PDRN SERUM
ZIVVI PDRN SERUM

Rated Excellent

(4.9/5 from Verified Customers)

ZIVVI PDRN SERUM

Clinically inspired skin repair that works where traditional rosacea treatments can't — helping visibly calm redness, strengthen your skin barrier, and restore an even complexion in as little as 6–8 weeks.

Developed to address the root cause of rosacea flare ups: chronic inflammation and a compromised skin barrier. Not just another cream that temporarily masks the redness.

Trusted by thousands of women who finally found relief from persistent redness and irritation.

With consistent use, many users report:

✓ Visibly calmer, less reactive skin
✓ Reduced facial redness and flushing
✓ Fewer and less intense flare ups
✓ Strengthened skin barriere
✓ Lasting hydration without irritation
✓ Skin that looks healthy and even toned, not inflamed

After 6 weeks, visibly see:

Reduced Wrinkles
Calmer Skin
Fewer Flare Ups
Stronger Barrier
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Before & After Results

See the transformations from real customers managing rosacea and skin redness.
Close-up of a person wearing a pink sweater against a plain background who have skin problem
Woman with long blonde hair smiling indoors who have clear skin

Your All-In-One Defense.

Real skin barrier repair takes time — consistency is your secret weapon.

Benefits illustration

Calms Chronic Inflammation at the Source

PDRN activates the adenosine A2A receptor, a master switch that helps quiet the overactive inflammatory response behind rosacea. This isn't a surface level fix. It addresses what drives redness from within.

Strengthens and Restores the Skin Barrier

A compromised barrier is one of the primary reasons rosacea skin stays irritated and reactive. PDRN supports the repair and reinforcement of your skin's protective layer, so it retains moisture better and becomes more resilient against triggers.

Deep Hydration Without Irritation

Provides lasting hydration while remaining lightweight and comfortable for even the most sensitive, rosacea prone skin. No stinging, no burning, no fragrance.

Visible Improvements With Consistency

With regular use, redness fades, flare ups become less frequent, and skin appears calmer, smoother, and more even toned as the benefits build gradually over time.

Benefits illustration

Your Journey Ahead

What to Expect When You Finally Address What Causes Your Rosacea. Real barrier repair and inflammation control doesn't happen overnight — and that's a good thing. Here's how most women experience results when using Zivvi PDRN Serum consistently.

Weeks 1–2

Your Skin Feels Different (Before It Looks Different)

The irritation starts to quiet down. Skin feels less reactive, less tight, and more comfortable throughout the day. The constant "hot" sensation begins to ease.

What's happening: PDRN is activating anti inflammatory pathways and beginning to stabilize the overactive blood vessels that cause flushing. Your skin barrier is starting to repair.

Weeks 3–4

The Redness Starts Fading

Others start noticing your skin looks calmer.The persistent pink or red flush begins to soften. Flare ups become less intense and less frequent. Skin holds moisture better and feels less sensitive to everyday triggers.

What’s happening:
Your skin barrier is strengthening. Chronic inflammation is being addressed at the cellular level, reducing the vascular response that causes visible redness.

Weeks 5–8

Visible Calm, Even Toned Skin

This is where it all comes together.
Redness is noticeably reduced. Skin looks even toned, comfortable, and healthy. Flare ups are significantly less frequent, and when they do happen, they resolve faster.

What’s happening:
The cumulative effect of daily PDRN application has meaningfully reduced inflammation, stabilized blood vessels, and rebuilt the skin barrier. Your skin is genuinely healthier, not just temporarily calm.

Beyond 8 Weeks

Results That Keep Building

Results don't plateau — they continue improving. With continued use, your skin's resilience keeps growing. Triggers that once caused major flare ups have less impact. This isn't about covering up rosacea. It's about giving your skin the tools to manage it from within.

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Our Key Statistics

75%

Felt calmer, less reactive skin Redness and irritation decreased noticeably within weeks.
82%

Noticed reduced facial redness Visible improvement in overall skin tone and flushing.
68%

Experienced fewer flare ups Less frequent and less intense rosacea episodes with continued use.
90%

Would keep using it Users chose to continue as part of their daily routine.

One Breakthrough. Full Skin Renewal at the Cellular Level.

See how our technology can treat common rosacea related skin issues at home.

One serum. Every night. 60 seconds.

Real inflammation control — not surface level cover ups.

Persistent Redness & Flushing +

Rosacea redness isn't just cosmetic — it's driven by chronic inflammation and unstable blood vessels beneath the skin. PDRN works at the cellular level to calm the overactive inflammatory response and stabilize vasodilation. Published research shows PDRN benefits the management of inflammation and angiogenesis in rosacea, helping reduce redness gradually and sustainably.

By activating the adenosine A2A receptor, PDRN helps your skin find a calmer baseline instead of constantly reacting.

Visible Blood Vessels & Broken Capillaries +

Visible blood vessels are often a hallmark of rosacea, caused by repeated microcapillary dilation that eventually becomes permanent. PDRN supportsvascular stabilization, helping to reduce the appearance of telangiectasia over time. Clinical surveys show approximately 90% of physicians who use polynucleotides for facial erythema report them as effective or highly effective.

As the skin barrier strengthens and inflammation decreases, the cycle of dilation and damage begins to slow.

Sensitive, Reactive Skin +

If your skin reacts to everything — weather changes, skincare products, stress, even hot drinks — your barrier is likely compromised. PDRN helps rebuild the skin's protective layer from within, reducing sensitivity and making your skin more resilient against everyday triggers.

Combined with niacinamide and low molecular weight hyaluronic acid, this formula hydrates and strengthens without any of the irritating ingredients that make rosacea worse.

Bumps, Papules & Uneven Texture +

Rosacea often causes small bumps and papules that give the skin an uneven, rough texture. PDRN supports the skin's natural repair process, helping smooth texture irregularities while calming the underlying inflammation that causes them.

Unlike harsh acne treatments that strip and irritate rosacea prone skin, PDRN works gently to restore smoothness without compromising your barrier.

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DAILY SKIN REPAIR REPLACES MONTHLY CLINIC TREATMENTS

Annual Savings $11,000 – $12,000 per year when switching to ZIVVI PDRN

Monthly Breakdown (Clinic-Equivalent Value)

  • PDRN Skin Repair Therapy (Comparable to in clinic rosacea treatments)  $300 USD
  • IPL / Laser Redness Reduction Sessions  $250 USD
  • Anti Inflammatory & Barrier Repair Infusions  $180 USD
  • Medical Grade Hydration (HA Boosters)  $120 USD
  • Vascular Stabilization Treatments $90 USD
  • Redness & Tone Correcting Treatments  $110 USD
Your Monthly Clinic & Professional Treatments $1,050 USD
ZIVVI PDRN Serum $89 USD
AWARD WINNING
INNOVATIVE TECHNOLOGIES
SCIENCE BACKED
AWARD WINNING
INNOVATIVE TECHNOLOGIES
SCIENCE BACKED
AWARD WINNING
INNOVATIVE TECHNOLOGIES
SCIENCE BACKED
AWARD WINNING
INNOVATIVE TECHNOLOGIES
SCIENCE BACKED

Us Vs.The Competition

See why ZIVVI works on the layer other rosacea products can't reach.

Us Vs.The Competition

See why ZIVVI works on the layer other rosacea products can't reach.

Most rosacea treatments focus on suppressing surface symptoms. ZIVVI PDRN Serum addresses the root cause — chronic inflammation and barrier damage — at the cellular level.

ZIVVI
PDRN SERUM
Others
(Rosacea Creams &Treatments)
Calms Inflammation at the Cellular Level (A2A Receptor)
Supports Vascular Stabilization to Reduce Redness
Clinically Inspired Ingredient Used in Wound Care (PDRN)
Cumulative Results That Improve Over Time
Gentle Enough for Rosacea Prone & Sensitive Skin
No Needles, No Clinic Visits
One Step Nightly Routine (60 Seconds)

Don't Just Trust Us.

Real experiences from real customers who love our products and service.

4.8/5 based on 2,500+ customer reviews

I've dealt with rosacea for over a decade. I've tried prescription creams, laser treatments, and every

'calming' serum on the market. Nothing gave me lasting relief. By week 3 with Zivvi, the constant redness

across my cheeks had visibly softened. By week 8, I could leave the house without concealer for the first

time in years. My skin actually looks calm. Not masked, not covered up — genuinely calm.

S
Sarah M. Verified customer

I spent thousands on IPL sessions and prescription treatments for my rosacea. They helped temporarily, but the redness always came back. I was skeptical about a serum making any difference when clinical treatments barely worked.

Three weeks in, my husband asked why my face wasn't as red. By week 6, the difference in photos was undeniable. My skin holds moisture better, reacts less to triggers, and the flare ups that used to happen weekly are now rare. I finally understand what 'barrier repair' actually means.

M
Michelle T. Verified customer

I'm 48 and my rosacea has gotten progressively worse over the past five years. Hot drinks, stress, even a slightly warm room would set my face on fire. I was exhausted from managing it.

A friend mentioned PDRN and the research behind it. The anti inflammatory mechanism made sense to me in a way that typical rosacea creams never did.

After 10 weeks with Zivvi, my skin is a different landscape. The background redness is dramatically reduced. I can drink coffee without my face flushing. My dermatologist noticed the improvement at my last appointment. This is the only thing that has addressed the actual cause, not just the symptoms.

P
Patricia R. Verified customer

I'll be honest — 'salmon DNA for rosacea' sounded absurd to me. But I read the published research on PDRN and inflammation, and the science was compelling enough to try.

My skin texture has transformed. The bumpy, uneven patches on my cheeks are smooth now. The redness that I thought was just 'my complexion' has faded to something that actually looks like normal skin. I'm 44 and people are asking what changed. Not 'what procedure did you get' — just 'your skin looks so much better.' That's exactly what I needed to hear.

J
Jennifer K. Verified customer

I was using metronidazole gel and azelaic acid for years. They kept things manageable but never actually improved my rosacea. My skin was always one trigger away from a flare up.

Zivvi was the missing piece. It works alongside my existing routine but addresses something deeper. By week 4, my flare ups were less intense. By week 8, they were less frequent. I still use my prescription products occasionally, but Zivvi is now the foundation of my routine.

S
Sandra M. Verified customer

Perimenopause made my rosacea explode. Redness that was once mild became constant and angry. Nothing I tried could keep up with the hormonal changes happening to my skin..

Then I found Zivvi. The difference after 8 weeks is remarkable. My skin is calmer, the redness has faded significantly, and I'm not constantly worrying about flare ups. My daughter said my skin looks 'peaceful.' That word has never applied to my face before. For any woman dealing with hormonal rosacea, this is worthtrying.

D
Diana L. Verified customer

I was spending hundreds on rosacea specific products that only managed symptoms. Temporary relief, back to red by afternoon. I was ready to accept this was just my life.

Zivvi proved me wrong. Real, sustained calm in my skin after 8 weeks. Not temporary suppression — actual improvement. The science behind PDRN and the A2A receptor finally explains why nothing else was working. They were all treating the surface while the inflammation kept raging underneath.

K
Karen W. Verified customer

Three things I noticed: 1) My skin doesn't react to temperature changes the way it used to — I can walk into a warm room without flushing. 2) The texture on my cheeks is smoother, and makeup sits evenly instead of clinging to rough patches. 3) People keep telling me I look 'healthy' instead of asking if I'm sunburnt. Week 7 and I've already ordered my second bottle.

R
Rebecca H. Verified customer

I'm a nurse, so I understand inflammation at a clinical level. When I read the research on PDRN and the adenosine A2A receptor pathway, I immediately recognized why this could help rosacea in ways that topical anti inflammatories can't.

My skin is measurably different after 9 weeks. Calmer, less reactive, more even in tone. The persistent erythema across my cheeks has faded significantly. This isn't a marketing gimmick — it's a legitimate anti inflammatory mechanism applied to a condition driven by chronic inflammation.

L
Lisa N. Verified customer

RISK-FREE Guarantee

We're so confident in the quality of our product that we offer a satisfaction guarantee. If you're not completely satisfied with your purchase, simply return the item within 60 days for a full refund.

CLAIM NOW
100% Satisfaction
Fast Shipping
Easy Returns

RISK-FREE Guarantee

We're so confident in the quality of our product that we offer a satisfaction guarantee. If you're not completely satisfied with your purchase, simply return the item within 60 days for a full refund.

CLAIM NOW
100% Satisfaction
Fast Shipping
Easy Returns

Frequently Asked Questions

Find answers to common questions about our products, shipping, returns, and more.

What exactly is PDRN? +

PDRN stands for polydeoxyribonucleotide. It's a DNA fragment derived from salmon that activates the adenosine A2A receptor — a master switch for cellular repair and anti inflammatory response. Originally developed for wound healing (burns, surgical incisions), it's now recognized as one of the most effective ingredients for managing chronic skin inflammation because it works at the cellular level whererosacea actually originates. Published research has specifically demonstrated PDRN's benefits in the management of rosacea

How does this help rosacea specifically? +

Rosacea is driven by chronic inflammation, unstable blood vessels, and a compromised skin barrier. PDRN addresses all three. It calms the overactive inflammatory response through A2A receptor activation, supports vascular stabilization to reduce persistent redness and flushing, and helps rebuild the damaged skin barrier that makes rosacea skin so reactive. Clinical surveys show approximately 90% of physicians who use polynucleotides for facial erythema rate them as effective or highly effective.

How is this different from prescription rosacea treatments? +

Most prescription treatments (metronidazole, azelaic acid, ivermectin) work by suppressing specific symptoms on the surface. They manage rosacea but rarely address the underlying causes. PDRN is different because it works at the cellular level to calm chronic inflammation, stabilize blood vessels, and rebuild the skin barrier. Many users find it works well alongside their existing prescription routine, addressing what those treatments can't.

What results can I expect and how fast? +

Most users notice their skin feels calmer and less reactive within the first 2 weeks. Visible reductions in redness and flushing typically appear around weeks 3–4. By weeks 6–8, the results are clearly visible: calmer skin, fewer flare ups, more even tone. Results continue to improve with ongoing use because PDRN supports genuine repair, not just temporary symptom suppression.

Can I use this with my other rosacea products? +

Yes. Zivvi PDRN Serum fits easily into most rosacea skincare routines. Apply it after cleansing and before your moisturizer. It pairs well with calming, barrier supporting ingredients and can complement prescription treatments. The lightweight formula absorbs quickly and layers well without irritation. If you use prescription topicals, apply Zivvi first as a hydrating and repairing foundation, then follow with your prescription product.

Is this suitable for sensitive, rosacea prone skin? +

Absolutely. Unlike many active ingredients that can trigger flare ups, PDRN has anti inflammatory properties that actually help calm sensitive skin. The formula is fragrance free and designed to be gentle on reactive skin. Niacinamide and low molecular weight hyaluronic acid further support barrier repair without irritation. If you have extremely sensitive skin, we recommend patch testing on a small area first.

Will this work for my type of rosacea? +

Zivvi PDRN Serum is effective for the most common presentations of rosacea, including persistent facial redness (erythematotelangiectatic), bumps and papules (papulopustular), and general skin sensitivity and reactivity. Because PDRN addresses the underlying inflammation that drives all subtypes, users across different rosacea presentations report meaningful improvement.

I've tried everything for my rosacea. Why should I believe this is different? +

Because it works on a fundamentally different level. Most rosacea products suppress symptoms at the surface. PDRN works at the cellular level where the inflammatory cascade actually originates. It activates the adenosine A2A receptor to calm chronic inflammation, stabilizes the blood vessels that cause flushing, and rebuilds the compromised barrier that keeps your skin reactive. If other products haven't provided lasting relief, it's likely because they couldn't address what's happening beneath the surface. PDRN can.

Is the "salmon DNA" thing real? Is it safe? +

Yes, it's real — and yes, it's safe. Salmon DNA was discovered to be remarkably compatible with human skin for tissue repair and regeneration. It's been used in medical wound care for decades and has extensive clinical research supporting its safety and efficacy, including specific research on rosacea management. The unusual name fades from your mind quickly once you see what it does for your skin

Do I need to use this forever? What happens if I stop? +

PDRN supports genuine repair, so the barrier strengthening and inflammation reduction you achieve are real improvements. However, rosacea is a chronic condition, so continued use helps maintain results and prevent regression. Think of it like managing any chronic condition: the improvements are real, but consistency gives you the best long term outcome.

Can I use this if I'm pregnant or breastfeeding? +

While PDRN is topical and not known to be harmful, we recommend consulting with your healthcare provider before using any new skincare products during pregnancy or breastfeeding.

Is my payment information secure? +

Absolutely. All payments are processed through secure, encrypted checkout. Your information is protected by the latest security standards.

What if it doesn't work for me? +

That's exactly why we offer our 60-Day Transformation Guarantee. If you don't see visible results — firmer, smoother, more radiant skin — simply contact us for a full refund. No questions asked. We're confident you'll see results, which is why we can make this guarantee.